ANDAORALTABLET
Approved
Mar 1997
Lifecycle
Post-LOE
Competitive Pressure
30/100
Clinical Trials
3
Mechanism of Action
CLINICAL PHARMACOLOGY Mechanism of Action The mechanism of action of captopril has not yet been fully elucidated. Its beneficial effects in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin-aldosterone system. However, there is no consistent…
Indications (9)
hypertensiondiabetic nephropathy (proteinuria > 500 mg/day) in patients with type I insulin-dependent diabetes mellitusretinopathythe treatment of congestive heart failure usually in combination with diureticsdigitalissurvival following myocardial infarction in clinically stable patients with left ventricular dysfunction manifestedto reduce the incidence of overt heart failuresubsequent hospitalizations for congestive heart failure in these patientsHeart Failure
Clinical Trials (3)
Bioequivalence Study Between Capoten Versus Captopril Reference Product in Healthy Adult Participants Under Fasting Conditions
Started Feb 2022
0Healthy Volunteers
Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin Activity
Started Jan 2008
150 enrolled
Primary Aldosteronism
Hemodynamic Effects of Aliskiren Compared to Captopril on the Kidney in Healthy Volunteers on a Low- and High- Sodium Diet
Started Oct 2005
32 enrolled
Hypertension