NDAORALTABLET, EXTENDED RELEASE
Approved
Dec 1986
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
CALAN SR (verapamil hydrochloride) by Pfizer is mechanism of action essential hypertension verapamil exerts antihypertensive effects by decreasing systemic vascular resistance, usually without orthostatic decreases in blood pressure or reflex tachycardia; bradycardia (rate less than 50 beats/min) is uncommon (1. First approved in 1986.
Drug data last refreshed 7h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CALAN SR (verapamil hydrochloride) is an extended-release oral calcium channel blocker approved in 1986 for essential hypertension and angina. It works by inhibiting calcium influx into vascular smooth muscle and cardiac tissue, reducing systemic vascular resistance and heart rate while dilating coronary arteries and preventing vasospasm. The drug is indicated for patients with hypertension, angina pectoris (including Prinzmetal's vasospastic angina), and certain arrhythmias.
$0.05MPart D
LOE ApproachingMature product approaching loss of exclusivity with minimal Medicare utilization signals a contracted brand team focused on cost management and generic transition planning.
Mechanism of Action
Mechanism of action Essential hypertension Verapamil exerts antihypertensive effects by decreasing systemic vascular resistance, usually without orthostatic decreases in blood pressure or reflex tachycardia; bradycardia (rate less than 50 beats/min) is uncommon (1.4%). During isometric or dynamic…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.