NDAORALTABLET, EXTENDED RELEASE
Approved
Dec 1986
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
CALAN SR (verapamil hydrochloride) by Pfizer is mechanism of action essential hypertension verapamil exerts antihypertensive effects by decreasing systemic vascular resistance, usually without orthostatic decreases in blood pressure or reflex tachycardia; bradycardia (rate less than 50 beats/min) is uncommon (1. First approved in 1986.
Drug data last refreshed 5h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CALAN SR is an extended-release oral formulation of verapamil hydrochloride, a calcium channel blocker that reduces systemic vascular resistance and dilates coronary arteries. It treats essential hypertension, angina (including vasospastic/Prinzmetal's angina), and certain arrhythmias by inhibiting calcium influx through slow channels. The mechanism decreases heart rate, prolongs AV node conduction, and reduces cardiac workload.
$0.05MPart D
LOE ApproachingDeclining
Declining claims and imminent loss of exclusivity signal a shrinking commercial footprint; brand teams are typically small and focused on defensive tactics or transition planning.
Mechanism of Action
Mechanism of action Essential hypertension Verapamil exerts antihypertensive effects by decreasing systemic vascular resistance, usually without orthostatic decreases in blood pressure or reflex tachycardia; bradycardia (rate less than 50 beats/min) is uncommon (1.4%). During isometric or dynamic…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.