CALAN SR

LOE Approaching

verapamil hydrochloride

NDAORALTABLET, EXTENDED RELEASE
Approved
Dec 1986
Lifecycle
LOE Approaching
Competitive Pressure
30/100

Mechanism of Action

Mechanism of action Essential hypertension Verapamil exerts antihypertensive effects by decreasing systemic vascular resistance, usually without orthostatic decreases in blood pressure or reflex tachycardia; bradycardia (rate less than 50 beats/min) is uncommon (1.4%). During isometric or dynamic…