CAFERGOT
LOE ApproachingNDARECTALSUPPOSITORYPriority Review
Approved
Apr 1953
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
Priority Review
CAFERGOT by Novartis is clinical pharmacology ergotamine is an alpha adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels and produces depression of central vasomotor centers. First approved in 1953.
Drug data last refreshed 5h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CAFERGOT is a combination product containing ergotamine (an alpha-adrenergic blocker and serotonin antagonist) and caffeine (a cranial vasoconstrictor) delivered as a rectal suppository for acute migraine treatment. The dual mechanism works by constricting cranial blood vessels and depressing central vasomotor centers, with caffeine enhancing efficacy without requiring higher ergotamine doses. This formulation is particularly valuable for migraine patients experiencing severe nausea and vomiting, as rectal administration bypasses the gastrointestinal tract and hepatic metabolism.
LOE Approaching
As a 70+ year-old product approaching loss of exclusivity, career opportunities are concentrated in specialty and niche migraine management teams; brand team size is likely lean with focus on retention rather than growth.
Mechanism of Action
CLINICAL PHARMACOLOGY Ergotamine is an alpha adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels and produces depression of central vasomotor centers. The compound also has the properties of serotonin antagonism. In comparison to…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.