CAFERGOT
LOE ApproachingNDAORALTABLET
Approved
Nov 1948
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
CAFERGOT by Novartis is clinical pharmacology ergotamine is an alpha adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels and produces depression of central vasomotor centers. First approved in 1948.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CAFERGOT is a combination of ergotamine and caffeine indicated for acute migraine headache relief. It works through alpha-adrenergic blocking and serotonin antagonism to constrict cranial blood vessels, with caffeine enhancing the vasoconstrictive effect. The rectal suppository formulation allows direct delivery to cranial vessels, bypassing hepatic metabolism in patients experiencing severe nausea and vomiting.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30); expect brand team focus to shift toward lifecycle management and cost-containment strategies rather than growth initiatives.
Mechanism of Action
CLINICAL PHARMACOLOGY Ergotamine is an alpha adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels and produces depression of central vasomotor centers. The compound also has the properties of serotonin antagonism. In comparison to…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.