BUSPAR
LOE ApproachingNDAORALCAPSULE
Approved
Dec 2000
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
4/8 — Partial
BUSPAR by Bristol Myers Squibb is the mechanism of action of buspirone is unknown. Approved for anxiety disorders, the short-term relief of the symptoms of anxiety. First approved in 2000.
Drug data last refreshed 6h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
BUSPAR (buspirone) is an oral small-molecule anxiolytic approved in 2000 for short-term relief of anxiety disorder symptoms. It works primarily through serotonin 5-HT1A receptor agonism with moderate D2-dopamine affinity, differing from benzodiazepines by lacking sedative, anticonvulsant, and muscle relaxant effects. The exact mechanism of action remains incompletely understood.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30/100), signaling potential team restructuring and transition focus toward LOE mitigation strategies.
Mechanism of Action
The mechanism of action of buspirone is unknown. Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. In vitro preclinical studies…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.