NDAINJECTIONINJECTABLE
Approved
Jul 1983
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
BUPIVACAINE HYDROCHLORIDE (bupivacaine hydrochloride) by Pfizer is impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. First approved in 1983.
Drug data last refreshed 21h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Bupivacaine hydrochloride is a long-acting local anesthetic administered via injection that blocks nerve impulses by increasing electrical excitation threshold and slowing nerve impulse propagation. It is used for regional anesthesia, nerve blocks, and infiltration anesthesia across surgical and pain management settings. The drug works by reversibly binding to sodium channels in nerve fibers, with clinical progression of anesthesia following a predictable order from pain to motor function loss.
LOE Approaching
As an established generic competing in a mature local anesthetic market with moderate competitive pressure (30), the brand team is likely focused on defensive positioning and operational efficiency rather than growth expansion.
Mechanism of Action
impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on bupivacaine hydrochloride offers stability and deep expertise in a foundational pharmaceutical product, but limited upside for career acceleration or innovative project exposure. Roles are concentrated in operations, compliance, and institutional sales rather than discovery, strategy, or growth-phase activities.
Supply Chain Manager
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.