BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE
LOE Approachingbupivacaine hydrochloride; epinephrine bitartrate
NDAINJECTIONINJECTABLE
Approved
Jul 1983
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (bupivacaine hydrochloride; epinephrine bitartrate) by Pfizer is impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Approved for regional anesthesia, analgesia for surgery, dental and 4 more indications. First approved in 1983.
Drug data last refreshed 4h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Bupivacaine hydrochloride combined with epinephrine bitartrate is a long-acting local anesthetic injectable used for regional anesthesia and analgesia across surgical, dental, and obstetrical procedures. It works by blocking nerve impulse generation and conduction, with epinephrine added as a vasoconstrictor to slow systemic absorption and prolong anesthetic duration.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30/100), indicating potential team consolidation and transition to generic defense strategies.
Mechanism of Action
impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction…
Indications (7)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.