NDAINJECTIONINJECTABLE
Approved
Jun 1960
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
BREVITAL SODIUM (methohexital sodium) by Pfizer is clinical pharmacology compared with thiamylal and thiopental, methohexital is at least twice as potent on a weight basis, and its duration of action is only about half as long. First approved in 1960.
Drug data last refreshed 20h ago · AI intelligence enriched Yesterday
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Brevital Sodium (methohexital sodium) is a rapid-acting barbiturate anesthetic administered intravenously, intramuscularly, or rectally for induction and short-duration anesthesia. It is approximately twice as potent as thiamylal and thiopental with a duration of action only half as long, making it suitable for brief procedures. The drug rapidly crosses the blood-brain barrier, inducing sleep within 30 seconds intravenously or 2–15 minutes via other routes.
LOE Approaching
This legacy injectable anesthetic is approaching loss of exclusivity with low commercial momentum, suggesting a small defensive team focused on operational efficiency rather than growth.
Mechanism of Action
CLINICAL PHARMACOLOGY Compared with thiamylal and thiopental, methohexital is at least twice as potent on a weight basis, and its duration of action is only about half as long. Although the metabolic fate of methohexital in the body is not clear, the drug does not appear to concentrate in fat…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.