NDAINJECTIONINJECTABLE
Approved
Jun 1960
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
BREVITAL SODIUM (methohexital sodium) by Pfizer is clinical pharmacology compared with thiamylal and thiopental, methohexital is at least twice as potent on a weight basis, and its duration of action is only about half as long. First approved in 1960.
Drug data last refreshed 9h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
BREVITAL SODIUM (methohexital sodium) is a short-acting barbiturate anesthetic administered via intravenous, intramuscular, or rectal routes. It induces rapid sleep within 30 seconds (IV) to 15 minutes (rectal) and is approximately twice as potent as thiamylal and thiopental with half the duration of action. The drug is metabolized hepatically via demethylation and oxidation, with minimal fat depot accumulation, enabling rapid recovery and fewer cumulative effects than other barbiturate anesthetics.
LOE Approaching
Product is approaching loss of exclusivity with moderate competitive pressure (30), signaling contracting brand team resources and focus shift to generic transition planning.
Mechanism of Action
CLINICAL PHARMACOLOGY Compared with thiamylal and thiopental, methohexital is at least twice as potent on a weight basis, and its duration of action is only about half as long. Although the metabolic fate of methohexital in the body is not clear, the drug does not appear to concentrate in fat…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.