NDAINJECTIONINJECTABLE
Approved
Nov 1981
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
BRETHINE (terbutaline sulfate) by Aspen Pharmacare is clinical pharmacology in vitro and in vivo pharmacologic studies have demonstrated that terbutaline exerts a preferential effect on beta 2 -adrenergic receptors. First approved in 1981.
Drug data last refreshed 19h ago · AI intelligence enriched 3d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Brethine (terbutaline sulfate) is a selective beta-2 adrenergic agonist administered by injection for rapid bronchospasm relief in patients with obstructive airway disease. It works by stimulating beta-2 receptors in bronchial smooth muscle, increasing intracellular cAMP levels and causing bronchodilation within 30 minutes, with maximum effect in 2-3 hours. The drug has been a standard acute respiratory therapy option since its 1981 approval.
LOE Approaching
As a legacy injectable with approaching loss of exclusivity and minimal linked job openings, this product likely has a small, maintenance-focused team with limited growth opportunities.
Mechanism of Action
CLINICAL PHARMACOLOGY In vitro and in vivo pharmacologic studies have demonstrated that terbutaline exerts a preferential effect on beta 2 -adrenergic receptors. While it is recognized that beta2-adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.