ANDAORALTABLET
Approved
Apr 2019
Lifecycle
Post-LOE
Competitive Pressure
30/100
Clinical Trials
8
Mechanism of Action
. Bosentan has a slightly higher affinity for ET A receptors than for ET B receptors. The clinical impact of dual endothelin blockage is unknown. Endothelin-1 (ET-1) is a neurohormone, the effects of which are mediated by binding to ET A and ET B receptors in the endothelium and vascular smooth…
Clinical Trials (5)
A Study in Healthy Men to Test How Bosentan Influences the Amount of Nerandomilast in the Blood
Started Aug 2025
16 enrolled
Healthy
A Study in Healthy Men to Test Whether Bosentan Influences the Amount of BI 425809 in the Blood
Started Mar 2023
14 enrolled
Healthy
Effect of BIA 5-1058 400 mg on the Steady State Pharmacokinetics of Bosentan
Started Feb 2018
Influence of Bosentan on the Pharmacokinetics of Nintedanib
Started Feb 2016
13 enrolled
Healthy
Influence of OATP1B1 and CYP2C9 Genotypes on the Pharmacokinetics of Bosentan Before and During Clarithromycin
Started Jun 2011
16 enrolled
Drug Interactions