NDATOPICALSPONGE
Approved
Mar 1989
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
BIOSCRUB (chlorhexidine gluconate) by Johnson & Johnson is clinical pharmacology periogard® (chlorhexidine gluconate oral rinse usp, 0. Approved for surgical site infection, staphylococcus aureus infection. First approved in 1989.
Drug data last refreshed Yesterday · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
BIOSCRUB is a topical chlorhexidine gluconate sponge formulation approved in 1989 for surgical site infection and Staphylococcus aureus infection prevention. The drug works through broad-spectrum antimicrobial activity, reducing aerobic and anaerobic bacteria counts by 54-97% with approximately 30% oral cavity retention and slow release into oral fluids. Poor systemic absorption (peak plasma level 0.206 µg/g) limits drug-drug interactions and systemic toxicity.
LOE Approaching
As a 35-year-old product approaching loss of exclusivity with 30% competitive pressure, the BIOSCRUB brand team likely faces contraction, favoring transition-focused roles in cost optimization and generic transition planning.
Mechanism of Action
CLINICAL PHARMACOLOGY PerioGard® (Chlorhexidine Gluconate Oral Rinse USP, 0.12%) provides antimicrobial activity during oral rinsing. The clinical significance of chlorhexidine gluconate oral rinse's antimicrobial activities is not clear. Microbiological sampling of plaque has shown a general…
Indications (2)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.