NDAINJECTIONINJECTABLE
Approved
Dec 1958
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
BICILLIN L-A (penicillin g benzathine) by Thayer Medical is mechanism of action penicillin g exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication. Approved for the treatment of infections due to penicillin-g-sensitive microorganisms, very prolonged serum levels common to this particular dosage form. First approved in 1958.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
BICILLIN L-A is a long-acting penicillin G benzathine injectable antibiotic approved in 1958 for treatment of penicillin-susceptible bacterial infections. It works by inhibiting bacterial cell-wall peptidoglycan synthesis, achieving bactericidal activity during active microbial multiplication. The formulation is notable for producing very prolonged serum levels, enabling extended dosing intervals.
$4.0MPart D
LOE ApproachingProduct is approaching loss of exclusivity with modest Part D spending ($4M), indicating a mature legacy franchise with limited growth opportunities and likely small dedicated team.
Mechanism of Action
Mechanism of Action Penicillin G exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell-wall peptidoglycan, rendering the cell wall osmotically unstable.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.