NDAINJECTIONINJECTABLE
Approved
Jun 1952
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
Drug Shortage Active
BICILLIN L-A is currently in shortage. Reason: Available. This may impact manufacturing, supply chain, and quality hiring at the manufacturer.
BICILLIN L-A (penicillin g benzathine) by Pfizer is mechanism of action penicillin g exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication. Approved for the treatment of infections due to penicillin-g-sensitive microorganisms, very prolonged serum levels common to this particular dosage form. First approved in 1952.
Drug data last refreshed Yesterday · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
BICILLIN L-A is a long-acting penicillin G benzathine injection approved in 1952 for treating infections caused by penicillin-susceptible microorganisms. It works by inhibiting bacterial cell-wall peptidoglycan synthesis, rendering cells osmotically unstable and achieving bactericidal effect. The benzathine formulation delivers very prolonged serum levels, enabling infrequent dosing.
LOE Approaching
As LOE approaches with moderate competitive pressure (30), positions supporting this product are likely consolidating; expect smaller teams focused on retention and supply chain stability rather than growth initiatives.
Mechanism of Action
Mechanism of Action Penicillin G exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell-wall peptidoglycan, rendering the cell wall osmotically unstable.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.