NDAINJECTIONINJECTABLE
Approved
May 1953
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
5/8 — Partial
BICILLIN C-R (penicillin g benzathine and penicillin g procaine) by Pfizer is mechanism of action penicillin g exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication. Approved for the treatment of infections, the treatment of the following in pediatric patients: moderately severe to severe infections of the upper-respiratory tract, scarlet fever and 3 more indications. First approved in 1953.
Drug data last refreshed Yesterday · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
BICILLIN C-R is a fixed-dose combination injectable containing penicillin G benzathine and penicillin G procaine, approved in 1953. It is indicated for treatment of moderately severe to severe infections including upper-respiratory tract infections, scarlet fever, erysipelas, and skin/soft-tissue infections caused by susceptible streptococci. The drug works through bactericidal inhibition of bacterial cell-wall peptidoglycan biosynthesis.
$35.0KPart D
LOE ApproachingLegacy product with minimal Part D spending ($35K in 2023) and declining patient base signals team restructuring and transition planning ahead of loss of exclusivity.
Mechanism of Action
Mechanism of Action Penicillin G exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell-wall peptidoglycan, rendering the cell wall osmotically unstable resulting in death of the…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.