NDAINTRAVENOUSSOLUTION
Approved
May 2018
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
11
Data completeness
6/8 — Strong
BELRAPZO (bendamustine hydrochloride) by Eagle Pharmaceuticals is purine-like benzimidazole ring. Approved for non-hodgkin's lymphoma, follicular lymphoma, mantle cell lymphoma and 1 more indications. First approved in 2018.
Drug data last refreshed 21h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
BELRAPZO (bendamustine hydrochloride) is a purine-like benzimidazole alkylating agent approved in 2018 for hematologic malignancies including non-Hodgkin's lymphoma, follicular lymphoma, mantle cell lymphoma, and chronic lymphocytic leukemia. It works by forming covalent DNA interstrand crosslinks that trigger cell death in both quiescent and dividing cells through multiple pathways. Administered intravenously, it represents a classical chemotherapy approach in an increasingly targeted therapy-dominated landscape.
Peak5.3 years to LOE
BELRAPZO is in peak commercial phase with stable market presence; team size likely modest given single-sponsor model and niche positioning versus larger competitors.
Mechanism of Action
purine-like benzimidazole ring. Mechlorethamine and its derivatives form electrophilic alkyl groups. These groups form covalent bonds with electron-rich nucleophilic moieties, resulting in interstrand DNA crosslinks. The bifunctional covalent linkage can lead to cell death via several pathways.…
Indications (4)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.