BAVENCIO
PeakmAbavelumab
BLAINTRAVENOUSINJECTABLEPriority Review
Approved
May 2017
Lifecycle
Peak
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
Priority Review
BAVENCIO (avelumab) is pd-l1 may be expressed on tumor cells and tumor-infiltrating immune cells and can contribute to the inhibition of the anti-tumor immune response in the tumor microenvironment. First approved in 2017.
Drug data last refreshed 3d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
BAVENCIO (avelumab) is a human monoclonal antibody (PD-L1 inhibitor) that restores anti-tumor immune responses by blocking the interaction between PD-L1 and its receptors (PD-1 and B7.1) on T cells. It is approved for 24 cancer indications ranging from urothelial and ovarian cancers to melanoma and glioblastoma. Avelumab also induces antibody-dependent cell-mediated cytotoxicity (ADCC), enhancing its immunomodulatory effect.
$2.0MPart D
PeakBAVENCIO is in peak commercial phase with modest Medicare Part D presence, suggesting stable but limited primary care penetration; focused oncology field team structure.
Mechanism of Action
PD-L1 may be expressed on tumor cells and tumor-infiltrating immune cells and can contribute to the inhibition of the anti-tumor immune response in the tumor microenvironment. Binding of PD-L1 to the PD-1 and B7.1 receptors found on T cells and antigen presenting cells suppresses cytotoxic T-cell…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
DEPECA-1 - A Phase II Study to Evaluate a First-line Systemic Therapy With Enfortumab Vedotin Plus Avelumab for Advanced and Metastatic Penile Carcinoma
Started Dec 2025
25 enrolled
Penile Squamous Cell Carcinoma (PSCC)
Copanlisib and Avelumab as a Maintenance Therapy for Advanced Bladder Cancer
Started Jun 2025
0Advanced Urothelial Carcinoma
Cetuximab Plus Platinum and Taxane-based Chemotherapy, Followed by Avelumab and Cetuximab, as First-line Treatment for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) Patients With a PD-L1 Combined Positive Score (CPS)≥1≤19.
Started Feb 2025
67 enrolled
Head and Neck Squamous Cell Carcinoma (HNSCC)Recurrent Head and Neck CancerMetastatic Head and Neck Cancer
Evaluation of Clinical Outcomes, Tolerability, and Costs of Avelumab Maintenance and Pembrolizumab Second-Line Therapy in Advanced Urothelial Cancer.
Started Sep 2024
35 enrolled
Urothelial Cancer
Study of Avelumab and Tuvusertib in Participants With Advanced Urothelial Cancer That Has Progressed on Prior Anti-PD-(L)1 Therapy (JAVELIN DDRiver Bladder)
Started Aug 2024
0Urothelial Carcinoma
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.