NDAORALSUSPENSION
Approved
Apr 1975
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
4/8 — Partial
BACTRIM (sulfamethoxazole; trimethoprim) by PharmaIN is clinical pharmacology bactrim is rapidly absorbed following oral administration. First approved in 1975.
Drug data last refreshed 21h ago · AI intelligence enriched 4d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
BACTRIM is a fixed-dose combination of sulfamethoxazole and trimethoprim, two synergistic antibacterial agents that inhibit bacterial folate synthesis at sequential steps. Rapidly absorbed orally with peak blood levels achieved 1–4 hours post-administration, the drug is used to treat a broad spectrum of bacterial infections including urinary tract infections, otitis media, and respiratory tract infections. The combination's mechanism leverages dual CYP2C9-mediated metabolism and renal excretion, achieving high urinary concentrations suitable for treating genitourinary infections.
$0.002BPart D
LOE ApproachingDeclining
This product is in late-stage lifecycle with minimal Part D activity; career opportunities focus on generic transition management and legacy brand maintenance rather than growth initiatives.
Mechanism of Action
CLINICAL PHARMACOLOGY BACTRIM is rapidly absorbed following oral administration. Both sulfamethoxazole and trimethoprim exist in the blood as unbound, protein-bound and metabolized forms; sulfamethoxazole also exists as the conjugated form. Sulfamethoxazole is metabolized in humans to at least 5…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.