NDAORALSUSPENSION
Approved
Apr 1975
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
4/8 — Partial
BACTRIM (sulfamethoxazole; trimethoprim) by PharmaIN is clinical pharmacology bactrim is rapidly absorbed following oral administration. First approved in 1975.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Bactrim is a fixed-dose combination of sulfamethoxazole and trimethoprim, two synergistic antibacterial agents that inhibit sequential steps in bacterial folate synthesis. It is rapidly absorbed orally and achieves therapeutic concentrations in blood and tissue within 1-4 hours, with a mean serum half-life of 8-10 hours for trimethoprim and 10 hours for sulfamethoxazole. Bactrim is indicated for a broad spectrum of bacterial infections including urinary tract infections, Pneumocystis jirovecii pneumonia, and other susceptible gram-positive and gram-negative infections.
$0.002BPart D
LOE ApproachingDeclining
Bactrim is approaching loss of exclusivity with minimal Part D spending ($2K in 2023) and only 28 claims, indicating a mature, low-volume legacy product with a contracting brand team.
Mechanism of Action
CLINICAL PHARMACOLOGY BACTRIM is rapidly absorbed following oral administration. Both sulfamethoxazole and trimethoprim exist in the blood as unbound, protein-bound and metabolized forms; sulfamethoxazole also exists as the conjugated form. Sulfamethoxazole is metabolized in humans to at least 5…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.