AVANDARYL
LOE Approachingglimepiride; rosiglitazone maleate
NDAORALTABLET
Approved
Nov 2005
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
cells. Sulfonylureas bind to the sulfonylurea receptor in the pancreatic beta-cell plasma membrane, leading to closure of the ATP-sensitive potassium channel, thereby stimulating the release of insulin.