NDAORALTABLET
Approved
Nov 2005
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
AVANDARYL (glimepiride; rosiglitazone maleate) by Teva is cells. Approved for type 2 diabetes mellitus ( ), type 1 diabetes mellitus, type 2 diabetes mellitus. First approved in 2005.
Drug data last refreshed 19h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
AVANDARYL is a fixed-dose combination tablet containing glimepiride (a meglitinide insulin secretagogue) and rosiglitazone maleate (a thiazolidinedione insulin sensitizer) approved for type 2 diabetes mellitus. The dual mechanism works by stimulating pancreatic insulin secretion while simultaneously enhancing peripheral insulin sensitivity in target tissues. This combination addresses both hyperglycemia drivers in type 2 diabetes.
LOE Approaching
Product is approaching loss of exclusivity with limited linked job availability, signaling a contracting brand team and reduced commercial opportunity.
Mechanism of Action
cells. Sulfonylureas bind to the sulfonylurea receptor in the pancreatic beta-cell plasma membrane, leading to closure of the ATP-sensitive potassium channel, thereby stimulating the release of insulin.
Indications (3)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.