NDATOPICALCREAM
Approved
Sep 2000
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
21
Data completeness
4/8 — Partial
AVAGE (tazarotene) by Almirall is form, the carboxylic acid of tazarotene, by deesterification. Approved for retinoid [epc]. First approved in 2000.
Drug data last refreshed 6h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
AVAGE is a topical retinoid cream containing tazarotene, approved in 2000 for the treatment of psoriasis and acne. Tazarotene is converted to tazarotenic acid, which binds to retinoic acid receptors (RARα, RARβ, RARγ) with selectivity for RARβ and RARγ to modulate gene expression. It represents a mature, well-established retinoid therapeutic option in dermatology.
LOE Approaching
Product is in late-stage life cycle with moderate competitive pressure (30/100), indicating potential team consolidation or transition focus.
Mechanism of Action
form, the carboxylic acid of tazarotene, by deesterification. Tazarotenic acid binds to all three members of the retinoic acid receptor (RAR) family: RARα, RARβ, and RARɣ, but shows relative selectivity for RARβ, and RARɣ and may modify gene expression. The clinical significance of these findings…
Pharmacologic Class:
Retinoid
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (21)
Traumatic Hemothorax Drainage and Daily Lavage
Started Mar 2025
20 enrolled
Hemothorax; Traumatic
Chlorhexidine Lavage for Recurrent Urinary Tract Infection
Started Dec 2024
136 enrolled
Urinary Tract InfectionsRecurrent Urinary Tract Infection
Does Joint Lavage Reduce Intraarticular Inflammation in High-energy Tibial Pilon Fractures?
Started Jan 2023
40 enrolled
Post-traumatic; ArthrosisTibial FracturesPost-Traumatic Osteoarthritis of Ankle
Combination of Halobetasol Propionate and Tazarotene Lotion (Duobrii®) for Palmoplantar Plaque Type Psoriasis
Started Nov 2020
22 enrolled
Palmoplantar PsoriasisPlaque Psoriasis
Liquid Biopsy for ctDNA in Peritoneal Lavage and Blood in Pancreatic Cancer
Started Aug 2020
80 enrolled
Pancreatic CancerPancreatic Adenocarcinoma
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.