NDATOPICALGEL
Approved
Jul 2007
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
6/8 — Strong
ATRALIN (tretinoin) by Pfizer is nucleus, but cutaneous levels of tretinoin in excess of physiologic concentrations occur following application of a tretinoin-containing topical drug product. Approved for acne vulgaris, photoaging, melasma and 1 more indications. First approved in 2007.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ATRALIN (tretinoin) is a topical retinoid gel approved in 2007 for acne vulgaris and photoaging. It works by decreasing cohesiveness of follicular epithelial cells, reducing microcomedo formation, and stimulating epithelial cell turnover through activation of retinoic acid nuclear receptors. The drug has expanded off-label use across dermatologic and oncologic indications ranging from melasma to acute promyelocytic leukemia.
$0.007BPart D
LOE ApproachingProduct approaching loss of exclusivity with minimal current Medicare spending signals a mature/declining brand with limited team expansion opportunities.
Mechanism of Action
nucleus, but cutaneous levels of tretinoin in excess of physiologic concentrations occur following application of a tretinoin-containing topical drug product. Although tretinoin activates three members of the retinoid acid (RAR) nuclear receptors (RARα, RARβ, and RARγ) which act to modify gene…
Pharmacologic Class:
Retinoid
Indications (4)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.