ATACAND

LOE Approaching

candesartan cilexetil

ANI Pharmaceuticals
NDAORALTABLET
Approved
Jun 1998
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20

Mechanism of Action

angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Candesartan blocks…

Indications (9)

hypertension in adultschildren 1 to <17 years of ageto lower blood pressureheart failure (NYHA class II-IV) in adults with left ventricular systolic dysfunction (ejection fraction ≤ 40%) to reduce cardiovascular deathchildren 1 to < 17 years of ageheart failure (NYHA class II-IV)hypertensionheart failurecardiovascular death

Clinical Trials (5)

NCT02047019Phase 3Withdrawn

Monotherapy-Controlled Study of Nifedipine Gastrointestinal Therapeutic System and Candesartan Cilexetil in Combination in Subjects With Essential Hypertension Inadequately Controlled on Candesartan Cilexetil

Started Dec 2017
0
Hypertension
NCT02254447Phase 1Completed

Relative Bioavailability Study of Candesartan Cilexetil Under Fasting Conditions

Started Dec 2014
18 enrolled
Cardiovascular Disease
NCT02006602Phase 1Completed

Bioavailability Study of Candesartan Cilexetil 16mg Tablet Under Fasting Conditions

Started Dec 2013
16 enrolled
Hypertension
NCT02006589Phase 1Completed

Bioavailability Study of Candesartan Cilexetil 8mg Tablet Under Fasting Conditions

Started Dec 2013
16 enrolled
Hypertension
NCT01788358Phase 3Completed

Open-Label Long-Term Safety and Efficacy Study of Fixed Dose Combination of Nifedipine Gastrointestinal Therapeutic System and Candesartan Cilexetil in Subjects With Moderate to Severe Essential Hypertension

Started Feb 2013
508 enrolled
Hypertension
Company
ANI Pharmaceuticals
ANI Pharmaceuticals
BAUDETTE, MN
External Resources
DailyMed
Full prescribing information
FDA Drugs@FDA
FDA approval history
RxNorm
Drug nomenclature & identifiers