NDAORALCAPSULE, EXTENDED RELEASE
Approved
Jul 2013
Lifecycle
Peak
Competitive Pressure
30/100
Clinical Trials
3
Data completeness
4/8 — Partial
Drug data last refreshed 23h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ASTAGRAF XL is an extended-release oral formulation of tacrolimus, a calcineurin inhibitor immunosuppressant used to prevent organ rejection in transplant recipients. The drug works by suppressing T-cell activation and proliferation, reducing the immune response against transplanted organs. It represents a formulation advancement over immediate-release tacrolimus, offering improved pharmacokinetic profiles and dosing convenience.
$0.448MPart D
PeakProduct is at peak lifecycle stage with modest Part D utilization (591 claims in 2023), indicating a mature, stable market position with limited growth trajectory.
Mechanism of Action
Mechanism of action data is being enriched from DailyMed and FDA sources. Check back soon for updated drug intelligence.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (3)
Trial to Evaluate Safety and Tolerability of Tacrolimus Extended-Release (Astagraf XL) in Human Leukocyte Antigen (HLA) Sensitized Kidney Transplant Recipients
Started Sep 2017
20 enrolled
End Stage Renal Disease
Dosing Requirements of Astagraf XL® in African American Kidney Transplant Recipients
Started May 2017
25 enrolled
Immunosuppression
To Compare the Effects of Immediate-release Tacrolimus and Astagraf XL on Donor-Specific Antibody (DSA) Formation and the Development of Immune Activation (IA) in de Novo Kidney Transplant Recipients
Started Sep 2016
599 enrolled
Kidney Transplantation
Career Relevance
ASTAGRAF XL currently shows zero linked job openings, reflecting its mature lifecycle and stable, niche market positioning in transplantation. Career opportunities are likely concentrated in transplant-focused commercial teams and specialty pharmacy channels rather than broad-based pharma roles.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.