NDAORALCAPSULE, EXTENDED RELEASE
Approved
Apr 1962
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
ARTANE (trihexyphenidyl hydrochloride) by Pfizer is clinical pharmacology trihexyphenidyl hydrochloride is the substituted piperidine salt, 3-(1-piperidyl)- 1-phenylcyclohexyl-1-propanol hydrochloride, which exerts a direct inhibitory effect upon the parasympathetic nervous system. First approved in 1962.
Drug data last refreshed 17h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Artane (trihexyphenidyl HCl) is an oral anticholinergic agent approved in 1962 that works by inhibiting the parasympathetic nervous system and relaxing smooth muscle. It is used primarily to treat extrapyramidal side effects associated with antipsychotic medications and Parkinson's disease symptoms. The drug's mechanism is similar to atropine but with a more favorable side effect profile.
LOE Approaching
As a legacy product approaching loss of exclusivity with moderate competitive pressure (30%), the brand team is likely focused on defensive positioning and cost management rather than expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY Trihexyphenidyl Hydrochloride is the substituted piperidine salt, 3-(1-piperidyl)- 1-phenylcyclohexyl-1-propanol hydrochloride, which exerts a direct inhibitory effect upon the parasympathetic nervous system. It also has a relaxing effect on smooth musculature; exerted both…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on Artane offers experience in legacy product management, defensive brand strategy, and generic transition planning rather than growth launches. Roles emphasize cost management, market maintenance, and stakeholder relationship preservation in a mature therapeutic category.
Brand Manager
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.