NDAORALCAPSULE, EXTENDED RELEASE
Approved
Apr 1962
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
ARTANE (trihexyphenidyl hydrochloride) by Pfizer is clinical pharmacology trihexyphenidyl hydrochloride is the substituted piperidine salt, 3-(1-piperidyl)- 1-phenylcyclohexyl-1-propanol hydrochloride, which exerts a direct inhibitory effect upon the parasympathetic nervous system. First approved in 1962.
Drug data last refreshed 20h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ARTANE (trihexyphenidyl hydrochloride) is an oral anticholinergic agent approved in 1962 that exerts direct inhibitory effects on the parasympathetic nervous system. It is used primarily to treat extrapyramidal side effects associated with antipsychotic medications and Parkinson's disease symptoms. The drug works similarly to atropine with a relaxing effect on smooth musculature and fewer severe side effects than its predecessors.
LOE Approaching
Legacy product approaching loss of exclusivity with modest competitive pressure (30%), signaling transition planning and potential team consolidation.
Mechanism of Action
CLINICAL PHARMACOLOGY Trihexyphenidyl Hydrochloride is the substituted piperidine salt, 3-(1-piperidyl)- 1-phenylcyclohexyl-1-propanol hydrochloride, which exerts a direct inhibitory effect upon the parasympathetic nervous system. It also has a relaxing effect on smooth musculature; exerted both…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on ARTANE positions professionals in a legacy product management environment focused on maintaining market share and optimizing profitability as exclusivity erodes. Career growth is limited by the product's mature stage and approaching LOE, making this role suitable for experienced professionals seeking stable, lower-complexity assignments rather than launch-phase innovation.
Brand Manager
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.