NDAORALCAPSULE, EXTENDED RELEASE
Approved
Apr 1962
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
ARTANE (trihexyphenidyl hydrochloride) by Pfizer is clinical pharmacology trihexyphenidyl hydrochloride is the substituted piperidine salt, 3-(1-piperidyl)- 1-phenylcyclohexyl-1-propanol hydrochloride, which exerts a direct inhibitory effect upon the parasympathetic nervous system. First approved in 1962.
Drug data last refreshed 3h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ARTANE (trihexyphenidyl hydrochloride) is an oral anticholinergic agent approved in 1962 that works by inhibiting parasympathetic nervous system activity and relaxing smooth muscle, similar to atropine but with fewer side effects. It is indicated for treating symptoms associated with Parkinson's disease and extrapyramidal reactions induced by antipsychotic medications. The drug exerts both direct effects on muscle tissue and indirect effects through parasympathetic blockade.
LOE Approaching
Product is in late lifecycle stage with moderate competitive pressure (30%), indicating defensive positioning and focus on retention rather than expansion initiatives.
Mechanism of Action
CLINICAL PHARMACOLOGY Trihexyphenidyl Hydrochloride is the substituted piperidine salt, 3-(1-piperidyl)- 1-phenylcyclohexyl-1-propanol hydrochloride, which exerts a direct inhibitory effect upon the parasympathetic nervous system. It also has a relaxing effect on smooth musculature; exerted both…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on ARTANE offers limited growth and career acceleration opportunities given its LOE-approaching status and minimal linked job openings. Roles focus on defending market share, managing generic competition, and optimizing profitability in a mature product category rather than driving innovation or expansion.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.