NDAORALELIXIR
Approved
May 1949
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
ARTANE (trihexyphenidyl hydrochloride) by Pfizer is clinical pharmacology trihexyphenidyl hydrochloride is the substituted piperidine salt, 3-(1-piperidyl)- 1-phenylcyclohexyl-1-propanol hydrochloride, which exerts a direct inhibitory effect upon the parasympathetic nervous system. First approved in 1949.
Drug data last refreshed 19h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ARTANE (trihexyphenidyl HCl) is an oral anticholinergic agent approved in 1949 that exerts inhibitory effects on the parasympathetic nervous system and relaxes smooth musculature. It is used primarily to manage extrapyramidal side effects (parkinsonism, akathisia, dystonia) associated with antipsychotic medications, and historically for idiopathic Parkinson's disease. Its therapeutic profile mirrors atropine with fewer and less severe adverse effects.
LOE Approaching
As a mature product approaching loss of exclusivity with moderate competitive pressure (30/100), brand teams face declining revenue and likely reduced headcount, signaling limited expansion opportunities.
Mechanism of Action
CLINICAL PHARMACOLOGY Trihexyphenidyl Hydrochloride is the substituted piperidine salt, 3-(1-piperidyl)- 1-phenylcyclohexyl-1-propanol hydrochloride, which exerts a direct inhibitory effect upon the parasympathetic nervous system. It also has a relaxing effect on smooth musculature; exerted both…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
ARTANE represents a career opportunity in legacy asset management within a mature, commoditized therapeutic class where skill development focuses on market access, generic competition management, and cost-effective distribution. This role suits professionals seeking stability over growth or those developing expertise in specialty/CNS portfolio management at a large sponsor like Pfizer.
Brand Manager (Specialty / Legacy)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.