NDAORALTABLETPriority Review
Approved
Sep 1998
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
12
Mechanism of Action
(a mitochondrial enzyme involved in de novo pyrimidine synthesis) and has antiproliferative activity. Several in vivo and in vitro experimental models have demonstrated an anti-inflammatory effect.
Pharmacologic Class:
Antirheumatic Agent
Indications (1)
Clinical Trials (5)
A Study of the Effectiveness of Additional Risk Minimization Measures Related to ARAVA® (Leflunomide) in Saudi Arabia
Started May 2025
3,500 enrolled
Rheumatoid ArthritisPsoriatic Arthritis
Laparoscopic Three-dimensional Versus Two-dimensional Sacral Colpopexy and Paravaginal Repair
Started Dec 2014
194 enrolled
Pelvic Organ ProlapseCystocele
A Study to Compare the Efficacy and Safety of Tacrolimus Capsules With Leflunomide Tablets in Lupus Nephritis Patients
Started Apr 2011
84 enrolled
Lupus Nephritis
Leflunomide EfficAcy Response Related to Dosing Regimen in Early Rheumatoid Arthritis
Started Dec 2007
124 enrolled
Arthritis, Rheumatoid
Leflunomide in Rheumatoid Arthritis
Started Apr 2004
60 enrolled
Arthritis, Rheumatoid