APTIVUS
LOE ApproachingNDAORALSOLUTIONPriority Review
Approved
Jun 2008
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
3
Data completeness
3/8 — Basic
Priority Review
APTIVUS by Boehringer Ingelheim is 12. First approved in 2008.
Drug data last refreshed 35m ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
APTIVUS (tipranavir) is an oral protease inhibitor antiretroviral drug used to treat HIV-1 infection in treatment-experienced patients. It works by inhibiting HIV protease, preventing viral replication. The drug must be co-administered with ritonavir, which boosts tipranavir plasma concentrations 29-fold through CYP3A inhibition.
LOE Approaching
Product approaching loss of exclusivity with competitive pressure at 30; team likely focused on lifecycle management and cost containment rather than growth initiatives.
Mechanism of Action
12.1 Mechanism of Action Tipranavir is an antiretroviral drug [ see ]. 12.2 Pharmacodynamics ECG Evaluation The effect of APTIVUS/ritonavir on the QTcF interval was measured in a study in which 81 healthy subjects received the following treatments twice daily for 2.5 days: APTIVUS/ritonavir (500…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.