ANTABUSE

LOE Approaching

disulfiram

NDAORALTABLETPriority Review
Approved
Aug 1951
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1

Mechanism of Action

CLINICAL PHARMACOLOGY: Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage. During alcohol metabolism following…

Clinical Trials (1)

NCT03198559Phase 1/2Terminated

Combination Latency Reversal With High Dose Disulfiram Plus Vorinostat in HIV-infected Individuals on ART

Started Aug 2017
5 enrolled
HIV Infections