NDAORALTABLETPriority Review
Approved
Aug 1951
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
7
Data completeness
4/8 — Partial
Priority Review
ANTABUSE (disulfiram) by Teva is clinical pharmacology: disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Approved for alcohol use disorder. First approved in 1951.
Drug data last refreshed Yesterday · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ANTABUSE (disulfiram) is an oral small molecule approved in 1951 for alcohol use disorder. It works by blocking alcohol metabolism at the acetaldehyde stage, causing a severe disulfiram-alcohol reaction if the patient ingests even small amounts of alcohol, creating a powerful deterrent. The drug does not influence alcohol elimination rate but produces increasing sensitivity with prolonged use.
LOE Approaching
As LOE approaches on a 1951 vintage, the brand is in contraction mode with likely reduced commercial team investment and focus shifted to generic transition planning.
Mechanism of Action
CLINICAL PHARMACOLOGY: Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage. During alcohol metabolism following…
Indications (1)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.