AMLODIPINE BESYLATE AND BENAZEPRIL HYDROCHLORIDE
Post-LOEamlodipine and benazepril hydrochloride
ANDAORALCAPSULE
Approved
Dec 2013
Lifecycle
Post-LOE
Competitive Pressure
30/100
Mechanism of Action
12.1 Mechanism of Action Benazepril Benazepril and benazeprilat inhibit ACE in human subjects and in animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance angiotensin II. Angiotensin II also stimulates aldosterone secretion by the…