AMLODIPINE BESYLATE AND ATORVASTATIN CALCIUM
Post-LOEamlodipine besylate and atorvastatin calcium
ANDAORALTABLET
Approved
Mar 2014
Lifecycle
Post-LOE
Competitive Pressure
30/100
Mechanism of Action
drugs, a dihydropyridine calcium channel blocker (amlodipine) and an HMG-CoA reductase inhibitor (atorvastatin). The amlodipine component of amlodipine besylate and atorvastatin calcium inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. The…
Indications (18)
hypertensionto lower blood pressure Lowering blood pressure reduces the risk of fatalnonfatal cardiovascular eventsprimarily strokesmyocardial infarctionsCoronary Artery Disease Atorvastatin is indicatedhyperlipidemia 1to lower blood pressureconfirmedsuspected vasospastic anginaatorvastatin is appropriatehospitalization for anginato reduce the risk of a coronary revascularization procedurerecently documented CAD by angiographywithout heart failurean ejection fraction <40%amlodipine is indicated to reduce the risk of hospitalization for anginaheart failure