Mechanism of Action
Mechanism of Action Amikacin, an aminoglycoside, binds to the prokaryotic ribosome, inhibiting protein synthesis in susceptible bacteria. It is bactericidal in vitro against Gram-positive and Gram-negative bacteria.
Indications (15)
the short-term treatment of serious infections due to susceptible strains of Gram-negative bacteriaincluding Pseudomonas speciesEscherichia colispecies of indole-positiveindole-negative ProteusProvidencia speciesKlebsiella-Enterobacter-Serratia speciesAcinetobacter ( Mima-Herellea ) speciesuncomplicated initial episodes of urinary tract infections unless the causative organisms are not susceptible to antibiotics having less potential toxicitydevelopment of drug-resistant bacteriamaintain the effectiveness of amikacinother antibacterial drugsamikacin should be used only to treatprevent infectionsstrongly suspected to be caused by susceptible bacteria