AMBRISENTAN (ambrisentan) by Pfizer is endothelin-1 (et-1) is a potent autocrine and paracrine peptide. Approved for pulmonary arterial hypertension (pah) (who group 1) in adult patients: • to improve exercise ability, delay clinical worsening, hypertension. First approved in 2019.
Drug data last refreshed 19h ago
Endothelin-1 (ET-1) is a potent autocrine and paracrine peptide. Two receptor subtypes, ET A and ET B , mediate the effects of ET-1 in the vascular smooth muscle and endothelium. The primary actions of ET A are vasoconstriction and cell proliferation, while the predominant actions of ET B are…
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Relative Bioavailability Study of Marketed and Lower Dose Ambrisentan in Healthy Adult Participants
Efficacy and Safety of Combination Ambrisentan and Tadalafil in Patients With Portopulmonary Hypertension
Study to Compare Triple Therapy (Oral Treprostinil, Ambrisentan, and Tadalafil) With Dual Therapy (Ambrisentan, Tadalafil, and Placebo) in Subjects With Pulmonary Arterial Hypertension
A Phase 1 Relative Bioavailability Study of Ambrisentan and Tadalfil Fixed Dose Combination Tablets in Healthy Subjects
The Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension Study