ANDAORALCAPSULE
Approved
Aug 2023
Lifecycle
Post-LOE
Competitive Pressure
30/100
Clinical Trials
15
Mechanism of Action
µ-opioid receptor with a Ki of 0.4 nM (0.2 ng/mL) and no measurable opioid-agonist effects in standard pharmacologic assays. The dissociation of [ H]-alvimopan from the human µ-opioid receptor is slower than that of other opioid ligands, consistent with its higher affinity for the receptor. At…
Clinical Trials (5)
Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol
Started Oct 2018
136 enrolled
Bladder Cancer
Alvimopan Use in Polytraumatized Patients
Started Sep 2017
3 enrolled
Post Operative Ileus
Trial of Alvimopan in Major Spine Surgery
Started Jun 2016
49 enrolled
Constipation
Alvimopan as Rescue in Post op Ileus
Started Dec 2015
14 enrolled
Colorectal SurgeryIleus
Intermountain Healthcare's Enhanced Recovery Protocol for Colon Surgery With and Without Alvimopan Use
Started May 2010
Ileus