NDAOPHTHALMICSOLUTION/DROPS
Approved
Mar 2001
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
6/8 — Strong
ALPHAGAN P (brimonidine tartrate) by AbbVie is alpha-2 adrenergic receptor agonist with a peak ocular hypotensive effect occurring at two hours post-dosing. Approved for ocular hypertension, glaucoma. First approved in 2001.
Drug data last refreshed Yesterday · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ALPHAGAN P (brimonidine tartrate) is an alpha-2 adrenergic receptor agonist ophthalmic solution approved in 2001 for the treatment of elevated intraocular pressure (IOP) in patients with open-angle glaucoma and ocular hypertension. The drug works through a dual mechanism: reducing aqueous humor production and increasing uveoscleral outflow, with peak ocular hypotensive effect occurring approximately two hours post-dosing. As a selective alpha-2 agonist, it represents a well-established therapeutic option in the glaucoma treatment armamentarium, distinct from prostaglandin analogs and beta-blockers that comprise much of the competitive space.
$0.2BPart D
Mechanism of Action
alpha-2 adrenergic receptor agonist with a peak ocular hypotensive effect occurring at two hours post-dosing. Fluorophotometric studies in animals and humans suggest that brimonidine tartrate has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow.
Indications (2)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.