ALOXI

LOE Approaching

palonosetron hydrochloride

NDAORALCAPSULE
Approved
Aug 2008
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20

Mechanism of Action

5-HT 3 receptor antagonist with a strong binding affinity for this receptor and little or no affinity for other receptors. Cancer chemotherapy may be associated with a high incidence of nausea and vomiting, particularly when certain agents, such as cisplatin, are used. 5-HT 3 receptors are located…

Clinical Trials (5)

NCT06062810Phase 2/3Active Not Recruiting

Pharmacogenomics ANDA SNP Clinical Study - Raloxifene and Single Nucleotide Polymorphisms

Started Jun 2025
600 enrolled
Breast Cancer
NCT03097588Phase 2Completed

Netupitant and Palonosetron Hydrochloride in Preventing Chemotherapy Induced Nausea and Vomiting in Patients With Cancer Undergoing BEAM Conditioning Regimen Before Stem Cell Transplant

Started Apr 2017
43 enrolled
Malignant Neoplasm
NCT00903396Phase 2Terminated

Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy in Patients With Primary Abdominal Cancer

Started Sep 2009
7 enrolled
Anal CancerCarcinoma of the AppendixColorectal Cancer+9 more
NCT00847821N/ATerminated

Observational Study Analyzing RNA Expression Of Endometrial Biopsy Samples From Placebo, Bazedoxifene/Conjugated Estrogens And Raloxifene

Started May 2009
185 enrolled
Postmenopause
NCT00636805Phase 2Terminated

Aloxi for Prevention of Chemotherapy Induced Nausea and Vomiting in Malignant Glioma Patients Receiving Irinotecan With Bevacizumab

Started May 2008
63 enrolled
Brain Cancer