NDAORALCAPSULE
Approved
Feb 2007
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
ALLI (orlistat) by GSK is lipase inhibitors [moa]. First approved in 2007.
Drug data last refreshed 20h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ALLI (orlistat) is an oral lipase inhibitor capsule approved in 2007 for weight management in adults. It works by inhibiting pancreatic and gastric lipases in the intestine, reducing dietary fat absorption by approximately 30%. ALLI is the OTC formulation of the prescription drug Xenical, indicated for use alongside diet and exercise in overweight patients.
LOE Approaching
As an OTC product in late lifecycle with approaching loss of exclusivity, ALLI teams are likely focused on defensive positioning and line extension rather than expansion, suggesting smaller commercial footprint.
Mechanism of Action
Lipase Inhibitors
Pharmacologic Class:
Intestinal Lipase Inhibitor
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral
Started Jan 2027
125 enrolled
Mitral RegurgitationMitral Valve DiseaseMitral Stenosis
The HANAROSTENT® Multi-Hole™ Biliary Stent is Indicated for Use in the Palliative Treatment of Biliary Strictures Produced by Malignant Neoplasms and the Study is to Demonstrate Clinical Safety and Performance of the Multi-Hole™ Stent for the Palliative Treatment of Malignant Biliary Obstruction.
Started Oct 2026
66 enrolled
Biliary Strictures Caused by Malignant Neoplasms
A Clinical Study on the Synergistic Effects of Zhen-Qi-Jie-Du Granules in Palliative Care for Advanced Colorectal Cancer
Started Sep 2026
1,540 enrolled
Colorectal Cancer
Unilateral and Staged Bilateral Pallidothalamic Tractotomy Using Exablate MRgFUS in Advanced Parkinson's Disease.
Started Sep 2026
120 enrolled
Parkinson Disease
Single Arm, Monocentric, Pilot Feasibility Study on an Interactive Virtual Reality Program in 20 Complex In-clinic Palliative Care Patients
Started Sep 2026
20 enrolled
Palliative CareRefractory PainAnxiety+3 more
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.