ALKERAN
LOE Approachingmelphalan hydrochloride
NDAINJECTIONINJECTABLEPriority Review
Approved
Nov 1992
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Mechanism of Action
CLINICAL PHARMACOLOGY: Melphalan is an alkylating agent of the bischloroethylamine type. As a result, its cytotoxicity appears to be related to the extent of its interstrand cross-linking with DNA, probably by binding at the Nposition of guanine. Like other bifunctional alkylating agents, it is…
Indications (1)
Clinical Trials (2)
Clinical Study of Safety and Tolerability of Melphalan Hydrochloride for R/R MM
Started Oct 2022
PK Study of Melphalan HCL & Alkeran for Injection of MA Conditioning in MM Patients of Autologous Transplantation
Started Jan 2010