NDAINJECTIONINJECTABLE
Approved
Dec 1986
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
3/8 — Basic
ALFENTA (alfentanil hydrochloride) by Pfizer is clinical pharmacology alfenta (alfentanil hydrochloride) is an opioid analgesic with a rapid onset of action. First approved in 1986.
Drug data last refreshed 16h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ALFENTA (alfentanil hydrochloride) is a rapid-onset opioid analgesic used for intraoperative analgesia and sedation in surgical and procedural settings. It works as a mu-opioid receptor agonist with a three-compartment pharmacokinetic profile and terminal elimination half-life of 90-111 minutes, enabling quick recovery compared to longer-acting opioids like fentanyl. ALFENTA is administered intravenously at doses ranging from 5-245 mcg/kg depending on procedure duration and patient factors.
LOE Approaching
As a legacy injectable opioid approaching loss of exclusivity with moderate competitive pressure, the brand team is likely in managed-care and hospital contract defense mode with smaller headcount than growth-stage products.
Mechanism of Action
CLINICAL PHARMACOLOGY ALFENTA (alfentanil hydrochloride) is an opioid analgesic with a rapid onset of action. At doses of 8-40 mcg/kg for surgical procedures lasting up to 30 minutes, ALFENTA provides analgesic protection against hemodynamic responses to surgical stress with recovery times…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.