NDAORALTABLET
Approved
Dec 1962
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
ALDORIL D30 (hydrochlorothiazide; methyldopa) by Merck & Co. is mechanism of action lisinopril inhibits angiotensin-converting enzyme (ace) in human subjects and animals. Approved for hypertension. First approved in 1962.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ALDORIL D30 is a fixed-dose combination of hydrochlorothiazide (a thiazide diuretic) and methyldopa (a centrally-acting antihypertensive) approved in 1962 for treatment of hypertension. The combination works through dual mechanisms: methyldopa reduces sympathetic outflow and peripheral vascular resistance, while hydrochlorothiazide promotes sodium and water excretion to decrease blood volume and vascular resistance. This product represents a legacy antihypertensive combination targeting patients with moderate to severe hypertension.
LOE Approaching
LOE-approaching status indicates shrinking market share and reduced commercial team investment; roles focus on managed decline and generic transition support.
Mechanism of Action
Mechanism of Action Lisinopril inhibits angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the…
Indications (1)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.