NDAORALCAPSULEPriority Review
Approved
Mar 1997
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
8
Mechanism of Action
unknown. In cell culture studies, anagrelide suppressed expression of transcription factors including GATA-1 and FOG-1 required for megakaryocytopoiesis, ultimately leading to reduced platelet production.
Clinical Trials (5)
Study to Evaluate the Effect of Omeprazole on the Pharmacokinetics of SPD422 (Anagrelide Hydrochloride) in Healthy Adult Participants
Started Feb 2019
20 enrolled
Healthy Volunteers
Agrylin Drug Use-Result Survey
Started Nov 2014
1,826 enrolled
Essential Thrombocythemia (ET)
Effect of Anagrelide Hydrochloride on Any Changes in Heart Function in Healthy Volunteers
Started Mar 2012
60 enrolled
Healthy
Long-term Safety of SPD422 in Japanese Adults With Essential Thrombocythaemia
Started Oct 2010
41 enrolled
Essential Thrombocythemia (ET)
Effect of SPD422 on Platelet Lowering and Safety in Japanese Adults With At Risk Essential Thrombocythaemia
Started Oct 2010
53 enrolled
Essential Thrombocythemia (ET)