AFATINIB (afatinib) by Boehringer Ingelheim is (erbb1), her2 (erbb2), and her4 (erbb4) and irreversibly inhibits tyrosine kinase autophosphorylation, resulting in downregulation of erbb signaling. Approved for lung cancer, lung cancer.
Drug data last refreshed 1mo ago
(ErbB1), HER2 (ErbB2), and HER4 (ErbB4) and irreversibly inhibits tyrosine kinase autophosphorylation, resulting in downregulation of ErbB signaling. Certain mutations in EGFR, including non-resistant mutations in its kinase domain, can result in increased autophosphorylation of the receptor,…
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