ADREVIEW
LOE Approachingiobenguane i-123
NDAINTRAVENOUSSOLUTIONPriority Review
Approved
Sep 2008
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
(NE). Iobenguane is, therefore, largely subject to the same uptake and accumulation pathways as NE. Iobenguane is taken up by the NE transporter in adrenergic nerve terminals and stored in the presynaptic storage vesicles. Iobenguane accumulates in adrenergically innervated tissues such as the…