ADEMPAS

Peak

riociguat

NDAORALTABLET
Approved
Oct 2013
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
37

Mechanism of Action

Guanylate Cyclase Stimulators

Pharmacologic Class:

Soluble Guanylate Cyclase Stimulator

Clinical Trials (5)

NCT05339087Phase 2Terminated

Efficacy and Safety of Riociguat in Incipient Pulmonary Vascular Disease as an Indicator for Early PAH

Started Oct 2022
35 enrolled
Pulmonary Vascular DisorderPrimary Pulmonary HypertensionSystemic Sclerosis+1 more
NCT04954742Phase 4Terminated

Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH

Started Apr 2022
30 enrolled
Primary Pulmonary Arterial HypertensionChronic Thromboembolic Pulmonary Hypertension
NCT04813926N/ACompleted

A Study to Learn About How Well Riociguat Works, How Safe it is and How it is Used Under Real World Conditions in Patients in the United States Who Are Receiving Riociguat for High Blood Pressure in the Arteries That Carry Blood From the Heart to the Lungs (Pulmonary Arterial Hypertension, PAH)

Started Jul 2021
500 enrolled
Pulmonary Arterial Hypertension
NCT04600492Phase 2Unknown

THERAPY-HYBRID-BPA Trial

Started Oct 2020
72 enrolled
Hypertension, Pulmonary
NCT02891850Phase 4Completed

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy

Started Jan 2017
225 enrolled
Pulmonary Arterial Hypertension

Loss of Exclusivity

LOE Date
Feb 18, 2034
96 months away
Patent Expiry
Feb 18, 2034

Patent Records (4)

Patent #ExpiryTypeUse Code
7173037
Dec 4, 2026
SubstanceProduct
10662188
Feb 18, 2034
SubstanceProduct
U-2834
11203593
Feb 18, 2034
SubstanceProduct
U-2835
12503469
Feb 18, 2034
Product
U-2835