ACTIVELLA
LOE ApproachingNDAORALTABLET
Approved
Apr 2000
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
ACTIVELLA by Novo Nordisk is characteristics. Approved for a woman with a uterus for: treatment of moderate to severe vasomotor symptoms due to menopause treatment of moderate to severe symptoms of vulvar, vaginal atrophy due to menopause limitations of use :, vaginal atrophy due to menopause and 1 more indications. First approved in 2000.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ACTIVELLA is an oral estrogen-progestin combination tablet approved for postmenopausal hormone replacement therapy (HRT), indicated for vasomotor symptoms, vulvovaginal atrophy, and endometrial protection. It works by binding to estrogen and progesterone receptors in target tissues to modulate hormone levels and reduce menopausal symptoms. The estradiol component is the primary active estrogen, while the progestin opposes estrogen's effects on the endometrium to reduce hyperplasia and cancer risk.
$0.125MPart D
LOE ApproachingProduct is approaching loss of exclusivity with minimal current Part D utilization (234 claims), suggesting a shrinking brand team and shift toward generic transition management.
Mechanism of Action
characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level. The primary source of estrogen in…
Indications (4)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.