Mechanism of Action
CLINICAL PHARMACOLOGY Alteplase is an enzyme (serine protease) that has the property of fibrin-enhanced conversion of plasminogen to plasmin. It produces limited conversion of plasminogen in the absence of fibrin. Alteplase binds to fibrin in a thrombus and converts the entrapped plasminogen to…
Clinical Trials (5)
Alteplase in Elderly Acute Ischemic Stroke (AIS) Patients During Hospitalization
Alteplase Treatment in Elderly Acute Ischaemic Stroke (AIS) Patients
A Study in Chinese Patients to Compare How Tenecteplase and Alteplase Given After a Stroke Improve Recovering of Physical Activity
A Study to Test Whether Different Doses of Alteplase Help People With Severe Breathing Problems Because of COVID-19
A Study in Healthy Men to Compare 2 Different Formulations of Alteplase