BLASINGLE-USEVIAL
Approved
Feb 1999
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
8
Data completeness
5/8 — Partial
ACTIMMUNE (interferon gamma-1b) by Amgen is interferon-stimulated genes. First approved in 1999.
Drug data last refreshed 31m ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ACTIMMUNE (interferon gamma-1b) is a recombinant Type 2 interferon that enhances macrophage oxidative metabolism, antibody-dependent cellular cytotoxicity, and natural killer cell activation. It is approved for chronic granulomatous disease (CGD) and severe malignant osteopetrosis (SMO), rare inherited immunodeficiency and bone disorders. The exact mechanism of efficacy in these conditions remains incompletely understood, as superoxide production changes do not predict treatment response.
$0.026BPart D
LOE ApproachingAs a mature biologic with LOE approaching, the ACTIMMUNE brand is likely transitioning from growth to legacy management with lean commercial teams focused on retention and efficiency.
Mechanism of Action
interferon-stimulated genes. The three major groups of interferons (alpha, beta, gamma) have partially overlapping biological activities that include immunoregulation such as increased resistance to microbial pathogens and inhibition of cell proliferation. Type 1 interferons (alpha and beta) bind…
Pharmacologic Class:
Interferon gamma
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.