ACTHREL
LOE ApproachingBLAINJECTIONINJECTABLEPriority Review
Approved
May 1996
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
Priority Review
ACTHREL by Ferring Pharmaceuticals is clinical pharmacology pharmacodynamics in normal subjects, intravenous administration of corticorelin results in a rapid and sustained increase of plasma acth levels and a near parallel increase of plasma cortisol. First approved in 1996.
Drug data last refreshed 9h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ACTHREL (corticorelin) is a synthetic corticotropin-releasing hormone (CRH) analog administered by intravenous injection that stimulates ACTH and cortisol release for diagnostic testing of hypothalamic-pituitary-adrenal (HPA) axis function. It is used to differentiate causes of adrenocorticotropin (ACTH) abnormalities and evaluate pituitary and adrenal function in patients with suspected endocrine disorders.
LOE Approaching
Product lifecycle is approaching loss of exclusivity; brand team focus likely shifting to generic defense and niche market retention rather than growth expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY Pharmacodynamics In normal subjects, intravenous administration of corticorelin results in a rapid and sustained increase of plasma ACTH levels and a near parallel increase of plasma cortisol. In addition, intravenous administration of corticorelin to normal subjects causes a…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.