ACTHREL
LOE ApproachingBLAINJECTIONINJECTABLEPriority Review
Approved
May 1996
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
Priority Review
ACTHREL by Ferring Pharmaceuticals is clinical pharmacology pharmacodynamics in normal subjects, intravenous administration of corticorelin results in a rapid and sustained increase of plasma acth levels and a near parallel increase of plasma cortisol. First approved in 1996.
Drug data last refreshed 35m ago · AI intelligence enriched 2d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ACTHREL (corticorelin) is a synthetic corticotropin-releasing hormone (CRH) analog administered via intravenous injection. It stimulates rapid and sustained release of plasma ACTH and cortisol, used diagnostically to assess hypothalamic-pituitary-adrenal (HPA) axis function. The drug elicits dose-dependent ACTH and cortisol responses with peak levels reached within 10-15 minutes for ACTH and 30-60 minutes for cortisol.
LOE Approaching
Product approaching loss of exclusivity with modest competitive pressure (30%); team size likely minimal given diagnostic-only use case and mature lifecycle status.
Mechanism of Action
CLINICAL PHARMACOLOGY Pharmacodynamics In normal subjects, intravenous administration of corticorelin results in a rapid and sustained increase of plasma ACTH levels and a near parallel increase of plasma cortisol. In addition, intravenous administration of corticorelin to normal subjects causes a…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.