NDAINJECTIONINJECTABLEPriority Review
Approved
Jul 1950
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
unknown. Acthar Gel and endogenous ACTH stimulate the adrenal cortex to secrete cortisol, corticosterone, aldosterone, and a number of weakly androgenic substances. Prolonged administration of large doses of Acthar Gel induces hyperplasia and hypertrophy of the adrenal cortex and continuous high…