NDAORALTABLET
Approved
Dec 1993
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
ACEON (perindopril erbumine) by Hikma is (perindopril erbumine) is a pro-drug for perindoprilat, which inhibits ace in human subjects and animals. Approved for nonfatal myocardial infarction () 1, nonfatal myocardial infarction, hypertension and 1 more indications. First approved in 1993.
Drug data last refreshed 22h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ACEON (perindopril erbumine) is an oral ACE inhibitor approved in 1993 for hypertension and secondary prevention of nonfatal myocardial infarction. It works by inhibiting angiotensin-converting enzyme, reducing angiotensin II-mediated vasoconstriction and aldosterone secretion. The drug is a prodrug that converts to perindoprilat, the active form responsible for blood pressure reduction and cardiovascular protection.
LOE Approaching
As a mature ACE inhibitor approaching loss of exclusivity under Hikma stewardship, the brand team is likely consolidating around defensive strategies and cost management rather than growth initiatives.
Mechanism of Action
(perindopril erbumine) is a pro-drug for perindoprilat, which inhibits ACE in human subjects and animals. The mechanism through which perindoprilat lowers blood pressure is believed to be primarily inhibition of ACE activity. ACE is a peptidyl dipeptidase that catalyzes conversion of the inactive…
Indications (3)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.