NDAORALTABLET
Approved
Dec 1999
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
4/8 — Partial
ACCURETIC (hydrochlorothiazide; quinapril hydrochloride) by R-Pharm US is mechanism of action lisinopril inhibits angiotensin-converting enzyme (ace) in human subjects and animals. Approved for hypertension. First approved in 1999.
Drug data last refreshed 7h ago · AI intelligence enriched 4d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ACCURETIC is a fixed-dose combination oral tablet containing hydrochlorothiazide (a thiazide diuretic) and quinapril hydrochloride (an ACE inhibitor) for the treatment of hypertension. It works by inhibiting angiotensin-converting enzyme to reduce angiotensin II-mediated vasoconstriction while the diuretic component reduces plasma volume. This dual mechanism provides complementary blood pressure reduction with potassium-sparing properties when combined.
LOE Approaching
ACCURETIC is approaching loss of exclusivity with moderate competitive pressure (score: 30/100), signaling a contracting brand team focused on generic defense and niche positioning.
Mechanism of Action
Mechanism of Action Lisinopril inhibits angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the…
Indications (1)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.