NDAORALTABLET
Approved
Nov 1991
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
3
Data completeness
4/8 — Partial
ACCUPRIL (quinapril hydrochloride) by R-Pharm US is clinical pharmacology mechanism of action quinapril is deesterified to the principal metabolite, quinaprilat, which is an inhibitor of ace activity in human subjects and animals. Approved for hypertension, to lower blood pressure, the management of heart failure and 3 more indications. First approved in 1991.
Drug data last refreshed 3h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ACCUPRIL (quinapril hydrochloride) is an ACE inhibitor oral tablet approved in 1991 for treating hypertension and heart failure. It works by inhibiting angiotensin-converting enzyme, reducing angiotensin II formation and decreasing blood pressure and cardiac workload.
LOE Approaching
Product approaching loss of exclusivity with limited promotional investment; expect consolidation of marketing team and shift toward maintenance mode.
Mechanism of Action
CLINICAL PHARMACOLOGY Mechanism of Action Quinapril is deesterified to the principal metabolite, quinaprilat, which is an inhibitor of ACE activity in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor, angiotensin II. The…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.